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Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine

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Baseline population: 45 years old on average, 65% female, BMI 39, mean weight 113 kg, 16 years of obesity history